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Imipenem monohydrate (亞胺培南一水物)

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Imipenem monohydrate,噻吩霉素的穩(wěn)定結(jié)晶衍生物,是一種抗生素,對(duì)革蘭氏陽性和革蘭氏陰性的需氧和厭氧細(xì)菌具有良好的抗性。Imipenem monohydrate,imipenem 的等效物,可被用于碳青霉烯類非易感性感染和銅綠假單胞菌生物膜感染。貨號(hào):
參數(shù)品牌:MCE
產(chǎn)品參數(shù)
品牌:MCE
型號(hào):HY-B1369
起訂量:1
規(guī)格::100 mg
價(jià)格::¥600
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產(chǎn)品詳情

Imipenem monohydrate (亞胺培南一水物)

Imipenem monohydrate,噻吩霉素的穩(wěn)定結(jié)晶衍生物,是一種抗生su,對(duì)革蘭氏陽性和革蘭氏陰性的需氧和厭氧細(xì)菌具有良好的抗性。Imipenem monohydrate,imipenem 的等效物,可被用于碳青霉烯類非易感性gan染和銅綠假單胞菌生物膜gan染。


生物活性

Imipenem monohydrate, a stable crystalline derivative of thienamycin, is an antibiotic and has the excellent activity against a broad range of gram-positive and gram-negative aerobic and anaerobic bacteria. Imipenem monohydrate, the equivalent of imipenem, can be used for carbapenem-nonsusceptible and P. aeruginosa biofilm infections


體外研究(In Vitro)

Imipenem is too unstable: 10% degradation at 25°C after 3.5 h[4].

The degradation rate constant of Imipenem is temperature dependent


分子量:317.36


Formula:C12H19N3O5S


CAS 號(hào):74431-23-5


中文名稱:亞胺培南一水物


運(yùn)輸條件:Room temperature in continental US; may vary elsewhere.


儲(chǔ)存方式:

Powder-20°C3 years

*該產(chǎn)品在溶液狀態(tài)不穩(wěn)定,建議您現(xiàn)用現(xiàn)配,即刻使用。


溶解性數(shù)據(jù)


H2O : 7.14 mg/mL (22.50 mM; Need ultrasonic)

DMSO : < 1 mg/mL (insoluble or slightly soluble)

配制儲(chǔ)備液
濃度溶劑體積質(zhì)量1 mg5 mg10 mg
1 mM3.1510 mL15.7550 mL31.5100 mL
5 mM0.6302 mL3.1510 mL6.3020 mL
10 mM0.3151 mL1.5755 mL3.1510 mL


參考文獻(xiàn)

[1]. Johann Motsch, et al. RESTORE-IMI 1: A Multicenter, Randomized, Double-blind Trial Comparing Efficacy and Safety of Imipenem/Relebactam vs Colistin Plus Imipenem in Patients With Imipenem-nonsusceptible Bacterial Infections. Clin Infect Dis. 2020 Apr 15;70(9):1799-1808.

[2]. Wang Hengzhuang, et al. In vivo pharmacokinetics/pharmacodynamics of colistin and imipenem in Pseudomonas aeruginosa biofilm infection. Antimicrob Agents Chemother. 2012 May;56(5):2683-90

[3]. F P Tally, et al. In vitro activity of N-formimidoyl thienamycin (MK0787). Antimicrob Agents Chemother. 1980 Oct;18(4):642-4.


Imipenem monohydrate (亞胺培南一水物)

Imipenem monohydrate (亞胺培南一水物)

分享到微信

×
Imipenem monohydrate,噻吩霉素的穩(wěn)定結(jié)晶衍生物,是一種抗生素,對(duì)革蘭氏陽性和革蘭氏陰性的需氧和厭氧細(xì)菌具有良好的抗性。Imipenem monohydrate,imipenem 的等效物,可被用于碳青霉烯類非易感性感染和銅綠假單胞菌生物膜感染。貨號(hào):
品牌:MCE
型號(hào):HY-B1369
起訂量:1
規(guī)格::100 mg
價(jià)格::¥600
15906629305
在線客服
產(chǎn)品詳情

Imipenem monohydrate (亞胺培南一水物)

Imipenem monohydrate,噻吩霉素的穩(wěn)定結(jié)晶衍生物,是一種抗生su,對(duì)革蘭氏陽性和革蘭氏陰性的需氧和厭氧細(xì)菌具有良好的抗性。Imipenem monohydrate,imipenem 的等效物,可被用于碳青霉烯類非易感性gan染和銅綠假單胞菌生物膜gan染。


生物活性

Imipenem monohydrate, a stable crystalline derivative of thienamycin, is an antibiotic and has the excellent activity against a broad range of gram-positive and gram-negative aerobic and anaerobic bacteria. Imipenem monohydrate, the equivalent of imipenem, can be used for carbapenem-nonsusceptible and P. aeruginosa biofilm infections


體外研究(In Vitro)

Imipenem is too unstable: 10% degradation at 25°C after 3.5 h[4].

The degradation rate constant of Imipenem is temperature dependent


分子量:317.36


Formula:C12H19N3O5S


CAS 號(hào):74431-23-5


中文名稱:亞胺培南一水物


運(yùn)輸條件:Room temperature in continental US; may vary elsewhere.


儲(chǔ)存方式:

Powder-20°C3 years

*該產(chǎn)品在溶液狀態(tài)不穩(wěn)定,建議您現(xiàn)用現(xiàn)配,即刻使用。


溶解性數(shù)據(jù)


H2O : 7.14 mg/mL (22.50 mM; Need ultrasonic)

DMSO : < 1 mg/mL (insoluble or slightly soluble)

配制儲(chǔ)備液
濃度溶劑體積質(zhì)量1 mg5 mg10 mg
1 mM3.1510 mL15.7550 mL31.5100 mL
5 mM0.6302 mL3.1510 mL6.3020 mL
10 mM0.3151 mL1.5755 mL3.1510 mL


參考文獻(xiàn)

[1]. Johann Motsch, et al. RESTORE-IMI 1: A Multicenter, Randomized, Double-blind Trial Comparing Efficacy and Safety of Imipenem/Relebactam vs Colistin Plus Imipenem in Patients With Imipenem-nonsusceptible Bacterial Infections. Clin Infect Dis. 2020 Apr 15;70(9):1799-1808.

[2]. Wang Hengzhuang, et al. In vivo pharmacokinetics/pharmacodynamics of colistin and imipenem in Pseudomonas aeruginosa biofilm infection. Antimicrob Agents Chemother. 2012 May;56(5):2683-90

[3]. F P Tally, et al. In vitro activity of N-formimidoyl thienamycin (MK0787). Antimicrob Agents Chemother. 1980 Oct;18(4):642-4.


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