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Asiaticoside (積雪草苷)

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Asiaticoside 是從積雪草中分到的三萜皂苷化合物，在瘢痕疙瘩成纖維細胞中，通過活化 Smad7，抑制 TGF-βRI 和 TGF-βRII，抑制 TGF-β/Smad 信號通路；Asiaticoside 具有抗氧化、抗?jié)兊裙πАＸ浱枺篐Y-N0439 ，CAS：16830-15-2
參數(shù)品牌：MCE
產(chǎn)品參數(shù)
品牌：MCE
型號：HY-N0439
起訂量：1
規(guī)格:：10mg
價格:：￥500
我知道了
在線客服
產(chǎn)品詳情

Asiaticoside (Synonyms: 積雪草苷)

Asiaticoside 是從積雪草中分到的三萜皂苷化合物，在瘢痕疙瘩成纖維細胞中，通過活化 Smad7，抑制 TGF-βRI 和 TGF-βRII，抑制 TGF-β/Smad 信號通路；Asiaticoside 具有抗氧化、抗?jié)兊裙πА?/span>

生物活性

Asiaticoside, a trisaccaride triterpene from Centella asiatica, suppresses TGF-β/Smad signaling through inducing Smad7 and inhibiting TGF-βRI and TGF-βRII in keloid fibroblasts; Asiaticoside shows antioxidant, anti-inflammatory, and anti-ulcer properties.


IC50 & Target

Human Endogenous Metabolite


體外研究(In Vitro)

Asiaticoside (0, 100, 250, and 500 mg/L) dose-dependently inhibits keloid fibroblasts proliferation. Asiaticoside (100, 250, and 500 mg/L) decreases the expression of collagen protein and mRNA, reduces the expression of TGF-bRI, TGF-bRII protein, and mRNA, increases the expression of Smad7, but does not affect Smad2, Smad3, Smad4, phosphorylated Smad2, and phosphorylated Smad3 in keloid fibroblasts[1]. Asiaticoside (12.5 and 50, and 25 and 50 μg/mL) prevents endothelial cells from hypoxia-induced inhibition of cell viability and NO production. Asiaticoside (50 μg/mL) also protects endothelial cells from hypoxia-induced apoptosis and upregulates and phosphorylation of AKT/eNOS in hypoxia-exposed HPAECs


體內(nèi)研究(In Vivo)

Asiaticoside (50 mg/kg daily) blocks the development of hypoxic pulmonary hypertension (PH), cardiovascular remodeling and endothelial cell injury in rats with pulmonary hypertension[2]. Asiaticoside (5, 15 or 45 mg/kg, p.o.) improves the learning and memory deficit, protects hippocampi against the impairment, decreases Aβ deposits in the hippocampus, and ameliorates impaired subcellular structure in rats treated with Aβ oligomers


分子量：959.12


Formula：C48H78O19


CAS 號：16830-15-2


中文名稱：積雪草苷


運輸條件：Room temperature in continental US; may vary elsewhere.


儲存方式：

Powder-20°C3 years

4°C2 years
In solvent-80°C6 months

-20°C1 month


溶解性數(shù)據(jù)

DMSO : 50 mg/mL (52.13 mM; Need ultrasonic)

配制儲備液
濃度溶劑體積質(zhì)量1 mg5 mg10 mg
1 mM1.0426 mL5.2131 mL10.4262 mL
5 mM0.2085 mL1.0426 mL2.0852 mL
10 mM0.1043 mL0.5213 mL1.0426 mL
*

請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；一旦配成溶液，請分裝保存，避免反復凍融造成的產(chǎn)品失效。
儲備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 儲存時，請在 6 個月內(nèi)使用，-20°C 儲存時，請在 1 個月內(nèi)使用。

In Vivo:

以下溶解方案都請先按照 In Vitro 方式配制澄清的儲備液，再依次添加助溶劑：

——為保證實驗結果的可靠性，澄清的儲備液可以根據(jù)儲存條件，適當保存；體內(nèi)實驗的工作液，建議您現(xiàn)用現(xiàn)配，當天使用； 以下溶劑前顯示的百
分比是指該溶劑在您配制終溶液中的體積占比；如在配制過程中出現(xiàn)沉淀、析出現(xiàn)象，可以通過加熱和/或超聲的方式助溶

  • 1.


    請依序添加每種溶劑： 10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (2.61 mM); Clear solution


  • 2.


    請依序添加每種溶劑： 10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (2.61 mM); Clear solution


  • 3.


    請依序添加每種溶劑： 10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (2.61 mM); Clear solution


  • 4.


    請依序添加每種溶劑： 10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (2.61 mM); Clear solution


  • 5.


    請依序添加每種溶劑： 10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (2.61 mM); Clear solution


  • 6.


    請依序添加每種溶劑： 10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (2.61 mM); Clear solution


  • 7.


    請依序添加每種溶劑： 10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (2.61 mM); Clear solution


  • 8.


    請依序添加每種溶劑： 10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (2.61 mM); Clear solution


  • 9.


    請依序添加每種溶劑： 5% DMSO    40% PEG300    5% Tween-80    50% saline

    Solubility: ≥ 2.5 mg/mL (2.61 mM); Clear solution


  • 10.


    請依序添加每種溶劑： 5% DMSO    95% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (2.61 mM); Clear solution


參考文獻

[1]. Tang B, et al. Asiaticoside suppresses collagen expression and TGF-β/Smad signaling through inducing Smad7 and inhibiting TGF-βRI and TGF-βRII in keloid fibroblasts. h Dermatol Res. 2011 Oct;303(8):563-72.

[2]. Wang X, et al. Effect of asiaticoside on endothelial cells in hypoxia?induced pulmonary hypertension. Mol Med Rep. 2018 Feb;17(2):2893-2900.

[3]. Zhang Z, et al. Asiaticoside ameliorates β-amyloid-induced learning and memory deficits in rats by inhibiting mitochondrial apoptosis and reducing inflammatory factors. Exp Ther Med. 2017 Feb;13(2):413-420.



Asiaticoside (積雪草苷)

Asiaticoside (積雪草苷)

分享到微信

×
Asiaticoside 是從積雪草中分到的三萜皂苷化合物，在瘢痕疙瘩成纖維細胞中，通過活化 Smad7，抑制 TGF-βRI 和 TGF-βRII，抑制 TGF-β/Smad 信號通路；Asiaticoside 具有抗氧化、抗?jié)兊裙π?。貨號：HY-N0439 ，CAS：16830-15-2
品牌：MCE
型號：HY-N0439
起訂量：1
規(guī)格:：10mg
價格:：￥500
15906629305
在線客服
產(chǎn)品詳情

Asiaticoside (Synonyms: 積雪草苷)

Asiaticoside 是從積雪草中分到的三萜皂苷化合物，在瘢痕疙瘩成纖維細胞中，通過活化 Smad7，抑制 TGF-βRI 和 TGF-βRII，抑制 TGF-β/Smad 信號通路；Asiaticoside 具有抗氧化、抗?jié)兊裙πА?/span>

生物活性

Asiaticoside, a trisaccaride triterpene from Centella asiatica, suppresses TGF-β/Smad signaling through inducing Smad7 and inhibiting TGF-βRI and TGF-βRII in keloid fibroblasts; Asiaticoside shows antioxidant, anti-inflammatory, and anti-ulcer properties.


IC50 & Target

Human Endogenous Metabolite


體外研究(In Vitro)

Asiaticoside (0, 100, 250, and 500 mg/L) dose-dependently inhibits keloid fibroblasts proliferation. Asiaticoside (100, 250, and 500 mg/L) decreases the expression of collagen protein and mRNA, reduces the expression of TGF-bRI, TGF-bRII protein, and mRNA, increases the expression of Smad7, but does not affect Smad2, Smad3, Smad4, phosphorylated Smad2, and phosphorylated Smad3 in keloid fibroblasts[1]. Asiaticoside (12.5 and 50, and 25 and 50 μg/mL) prevents endothelial cells from hypoxia-induced inhibition of cell viability and NO production. Asiaticoside (50 μg/mL) also protects endothelial cells from hypoxia-induced apoptosis and upregulates and phosphorylation of AKT/eNOS in hypoxia-exposed HPAECs


體內(nèi)研究(In Vivo)

Asiaticoside (50 mg/kg daily) blocks the development of hypoxic pulmonary hypertension (PH), cardiovascular remodeling and endothelial cell injury in rats with pulmonary hypertension[2]. Asiaticoside (5, 15 or 45 mg/kg, p.o.) improves the learning and memory deficit, protects hippocampi against the impairment, decreases Aβ deposits in the hippocampus, and ameliorates impaired subcellular structure in rats treated with Aβ oligomers


分子量：959.12


Formula：C48H78O19


CAS 號：16830-15-2


中文名稱：積雪草苷


運輸條件：Room temperature in continental US; may vary elsewhere.


儲存方式：

Powder-20°C3 years

4°C2 years
In solvent-80°C6 months

-20°C1 month


溶解性數(shù)據(jù)

DMSO : 50 mg/mL (52.13 mM; Need ultrasonic)

配制儲備液
濃度溶劑體積質(zhì)量1 mg5 mg10 mg
1 mM1.0426 mL5.2131 mL10.4262 mL
5 mM0.2085 mL1.0426 mL2.0852 mL
10 mM0.1043 mL0.5213 mL1.0426 mL
*

請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；一旦配成溶液，請分裝保存，避免反復凍融造成的產(chǎn)品失效。
儲備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 儲存時，請在 6 個月內(nèi)使用，-20°C 儲存時，請在 1 個月內(nèi)使用。

In Vivo:

以下溶解方案都請先按照 In Vitro 方式配制澄清的儲備液，再依次添加助溶劑：

——為保證實驗結果的可靠性，澄清的儲備液可以根據(jù)儲存條件，適當保存；體內(nèi)實驗的工作液，建議您現(xiàn)用現(xiàn)配，當天使用； 以下溶劑前顯示的百
分比是指該溶劑在您配制終溶液中的體積占比；如在配制過程中出現(xiàn)沉淀、析出現(xiàn)象，可以通過加熱和/或超聲的方式助溶

  • 1.


    請依序添加每種溶劑： 10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (2.61 mM); Clear solution


  • 2.


    請依序添加每種溶劑： 10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (2.61 mM); Clear solution


  • 3.


    請依序添加每種溶劑： 10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (2.61 mM); Clear solution


  • 4.


    請依序添加每種溶劑： 10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (2.61 mM); Clear solution


  • 5.


    請依序添加每種溶劑： 10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (2.61 mM); Clear solution


  • 6.


    請依序添加每種溶劑： 10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (2.61 mM); Clear solution


  • 7.


    請依序添加每種溶劑： 10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (2.61 mM); Clear solution


  • 8.


    請依序添加每種溶劑： 10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (2.61 mM); Clear solution


  • 9.


    請依序添加每種溶劑： 5% DMSO    40% PEG300    5% Tween-80    50% saline

    Solubility: ≥ 2.5 mg/mL (2.61 mM); Clear solution


  • 10.


    請依序添加每種溶劑： 5% DMSO    95% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (2.61 mM); Clear solution


參考文獻

[1]. Tang B, et al. Asiaticoside suppresses collagen expression and TGF-β/Smad signaling through inducing Smad7 and inhibiting TGF-βRI and TGF-βRII in keloid fibroblasts. h Dermatol Res. 2011 Oct;303(8):563-72.

[2]. Wang X, et al. Effect of asiaticoside on endothelial cells in hypoxia?induced pulmonary hypertension. Mol Med Rep. 2018 Feb;17(2):2893-2900.

[3]. Zhang Z, et al. Asiaticoside ameliorates β-amyloid-induced learning and memory deficits in rats by inhibiting mitochondrial apoptosis and reducing inflammatory factors. Exp Ther Med. 2017 Feb;13(2):413-420.



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