取消
清空記錄
歷史記錄
清空記錄
歷史記錄
產(chǎn)品中心
瀏覽器自帶分享功能也很好用哦~
在線客服
客服一
5-Ethynyl-2'-deoxyuridine
5-Ethynyl-2'-deoxyuridine (EdU) 是一種胸腺嘧啶核苷類似物，在細(xì)胞增殖時能夠插入正在復(fù)制的 DNA 分子中， EdU 與染料的共軛反應(yīng)可以進(jìn)行高效快速的細(xì)胞增殖檢測分析。5-Ethynyl-2'-deoxyuridine 是一種 PROTAC linker，屬于 alkyl chain 類?？捎糜诤铣?PROTAC 分子。
生物活性
5-Ethynyl-2'-deoxyuridine (EdU), a thymidine analogue, is incorporated into cellular DNA during DNA replication and the subsequent reaction of EdU with a fluorescent azide in a “Click” reaction. EdU staining is a fast, sensitive and reproducible method to study cell proliferation[1]. 5-Ethynyl-2'-deoxyuridine is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs
IC50 & Target：Alkyl-Chain
體外研究(In Vitro)
5-Ethynyl-2'-deoxyuridine (EdU) staining is a fast, sensitive and reproducible method to study cell proliferation in the central nervous system[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[
體內(nèi)研究(In Vivo)
The number of 5-Ethynyl-2'-deoxyuridine (EdU; a single injection of EdU intraperitoneally at a dose of 10, 20, 50, 100 or 200 mg/kg body weight) positive cells in the dentate gyrus slightly increased in a dose-dependent manner in two month old female mice
| Animal Model: | Two month old female mice[1] |
| Dosage: | 10, 20, 50, 100 or 200 mg/kg |
| Administration: | Single injection; intraperitoneally; 4 hours after EdU injection, brains were processed for EdU staining. |
| Result: | EdU positive cell numbers slightly increased in a dose-dependent manner both in control and running mice. |
分子量：252.22
Formula：C11H12N2O5
CAS 號：61135-33-9
運(yùn)輸條件：Room temperature in continental US; may vary elsewhere.
儲存方式：
4°C, protect from light
*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
溶解性數(shù)據(jù)
DMSO : 50 mg/mL (198.24 mM; Need ultrasonic)
H2O : 25 mg/mL (99.12 mM; Need ultrasonic)
| 濃度溶劑體積質(zhì)量 | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 3.9648 mL | 19.8240 mL | 39.6479 mL |
| 5 mM | 0.7930 mL | 3.9648 mL | 7.9296 mL |
| 10 mM | 0.3965 mL | 1.9824 mL | 3.9648 mL |
請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；一旦配成溶液，請分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
儲備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C 儲存時，請?jiān)?6 個月內(nèi)使用，-20°C 儲存時，請?jiān)?1 個月內(nèi)使用。
參考文獻(xiàn)
在線客服客服一5-Ethynyl-2'-deoxyuridine
5-Ethynyl-2'-deoxyuridine (EdU) 是一種胸腺嘧啶核苷類似物，在細(xì)胞增殖時能夠插入正在復(fù)制的 DNA 分子中， EdU 與染料的共軛反應(yīng)可以進(jìn)行高效快速的細(xì)胞增殖檢測分析。5-Ethynyl-2'-deoxyuridine 是一種 PROTAC linker，屬于 alkyl chain 類?？捎糜诤铣?PROTAC 分子。
生物活性
5-Ethynyl-2'-deoxyuridine (EdU), a thymidine analogue, is incorporated into cellular DNA during DNA replication and the subsequent reaction of EdU with a fluorescent azide in a “Click” reaction. EdU staining is a fast, sensitive and reproducible method to study cell proliferation[1]. 5-Ethynyl-2'-deoxyuridine is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs
IC50 & Target：Alkyl-Chain
體外研究(In Vitro)
5-Ethynyl-2'-deoxyuridine (EdU) staining is a fast, sensitive and reproducible method to study cell proliferation in the central nervous system[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[
體內(nèi)研究(In Vivo)
The number of 5-Ethynyl-2'-deoxyuridine (EdU; a single injection of EdU intraperitoneally at a dose of 10, 20, 50, 100 or 200 mg/kg body weight) positive cells in the dentate gyrus slightly increased in a dose-dependent manner in two month old female mice
| Animal Model: | Two month old female mice[1] |
| Dosage: | 10, 20, 50, 100 or 200 mg/kg |
| Administration: | Single injection; intraperitoneally; 4 hours after EdU injection, brains were processed for EdU staining. |
| Result: | EdU positive cell numbers slightly increased in a dose-dependent manner both in control and running mice. |
分子量：252.22
Formula：C11H12N2O5
CAS 號：61135-33-9
運(yùn)輸條件：Room temperature in continental US; may vary elsewhere.
儲存方式：
4°C, protect from light
*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
溶解性數(shù)據(jù)
DMSO : 50 mg/mL (198.24 mM; Need ultrasonic)
H2O : 25 mg/mL (99.12 mM; Need ultrasonic)
| 濃度溶劑體積質(zhì)量 | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 3.9648 mL | 19.8240 mL | 39.6479 mL |
| 5 mM | 0.7930 mL | 3.9648 mL | 7.9296 mL |
| 10 mM | 0.3965 mL | 1.9824 mL | 3.9648 mL |
請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；一旦配成溶液，請分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
儲備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C 儲存時，請?jiān)?6 個月內(nèi)使用，-20°C 儲存時，請?jiān)?1 個月內(nèi)使用。
參考文獻(xiàn)
取消
清空記錄
歷史記錄
清空記錄
歷史記錄
