IGF-I/IGF-1 蛋白, Mouse (His)是一種促進(jìn)有絲分裂的細(xì)胞因子，與 IGF 受體結(jié)合，能夠調(diào)節(jié)多種組織的生長，如神經(jīng)組織、淋巴組織、生殖組織、平滑肌、內(nèi)皮細(xì)胞和骨骼等，同時具有調(diào)節(jié)神經(jīng)保護(hù)的作用。

種屬：Mouse

表達(dá)系統(tǒng)：E. coli

標(biāo)簽：C-6*His

蛋白編號：P05017 (G49-A118)

基因 ID：16000

同用名：IGF1; IGF-1; insulin-like growth factor 1; Insulin-like growth factor I; Somatomedin C; somatomedin-C

氨基酸序列：GPETLCGAELVDALQFVCGPRGFYFNKPTGYGSSIRRAPQTGIVDECCFRSCDLRRLEMYCAPLKPTKAA

分子量：Approximately 12.0 kDa

純度：Greater than 95% as determined by reducing SDS-PAGE.

生物活性：Data is not available.

性狀：Lyophilized powder.

組分：Lyophilized from a 0.2 μm filtered solution of 20 mM NaAc, pH 4.5.

內(nèi)毒素含量：<1 EU/μg, determined by LAL method.

復(fù)溶方法：It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

保存條件 & 期限：Stored at -20°C. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer. It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

運(yùn)輸條件：Room temperature in continental US;may vary elsewhere.

描述：Insulin-like growth factor (IGF) system has been shown to modulate growth in many tissues, such as nervous tissue, lymphoid tissue, reproductive tissue, smooth muscle, endothelium, and bone. Insulin-like Growth factor-1 (IGF-I) is produced by osteoblasts, and its mitogenic effects are mediated by their binding to the IGF plasma membrane receptors. The IGF type 1 receptor binding to both IGF-I and IGF-II, is thought to be the predominate receptor involved in mediating the effects of these growth factors in most cell types, including osteoblasts^[1]. Insulin-like growth factor-1 (IGF-1) is a neurotrophic factor capable of mediating neuroprotective and neuroplasticity mechanisms. Targeted overexpression of IGF-1 enhances the generation of hippocampal newborn neurons in brain-injured mice

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