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Albendazole (Synonyms: 阿苯達(dá)唑; SKF-62979)
Albendazole (SKF-62979) 是一種口服有效的廣譜的抗寄生蟲劑，具有高效、低宿主毒性的特點(diǎn)，可用于人類和動(dòng)物胃腸道寄生蟲的研究。Albendazole 可誘導(dǎo)癌細(xì)胞的凋亡和自噬，并抗細(xì)胞增殖和抑制細(xì)胞周期進(jìn)程。Albendazole 還能抑制微管蛋白的聚合和 HIF-1α、VEGF 的表達(dá)，具有抗氧化活性，能抑制癌細(xì)胞的糖酵解過程。
生物活性
Albendazole (SKF-62979) is an orally active and broad-spectrum parasiticide with high effectiveness and low host toxicity, is used for the research of gastrointestinal parasites in humans and animals. Albendazole induces apoptosis and autophagy in cancer cells. Albendazole also inhibits tubulin polymerization and HIF-1α, VEGF expression, has antioxidant activity, and inhibits the glycolytic process in cancer cells[1][2][3][4][5].
IC50 & Target
parasites, tubulin[1][2].
HIF-1α, VEGF[3].
體外研究(In Vitro)
Albendazole (100, 500, 1000 nM; 1, 3, or 5 days) inhibits cell proliferation in a dose-dependent manner[1].
Albendazole (100, 250, 500, 1000 nM; 3 days) arrests SKHEP-1 cells at both G0–G1 (250, 500 nM) and G2-M (1000 nM) phases of the cycle[1].
Albendazole (5 μM; 24, 36 h) mainly induces early apoptosis in HCT-15 cells and late apoptosis in HCT-1 16, HT29, SW480 cells accompanied with cleavage of PARP and caspase-3 in a time-dependent manner[2].
Albendazole (5 μM; 24, 36 h) induces autophagy via increasing autophagy-related protein (such as LC3, Atg7, p-beclin-1, and beclin-1) expression level in HCT-15, HCT-1 16, HT29, and SW480 cells[2].
Albendazole (500 nM, 24 h) inhibits hypoxia-induced HIF-1α expression and VEGF expression in A549 cells[3].
| Cell Line: | SKHEP-1 cells |
| Concentration: | 100, 500, 1000 nM |
| Incubation Time: | 1, 3, or 5 days |
| Result: | Inhibited cell proliferation in a dose-dependent manner. |
體內(nèi)研究(In Vivo)
Albendazole (10 mg/kg; i.g.; once a day for 30 days) reduces Echinococcus granulosus cyst weights in mice[4].
Albendazole (300 mg/kg; p.o.; per day in two divided dose for 20 days) profoundly suppresses tumor growth in vivo[1].
| Animal Model: | Female BALB/c mice (10-week-age; Echinococcus granulosus infection model)[4]. |
| Dosage: | 10 mg/kg |
| Administration: | Oral gavage; once a day for 30 days. |
| Result: | Reduced Echinococcus granulosus cyst weights. |
分子量：265.33
Formula：C12H15N3O2S
CAS 號(hào)：54965-21-8
中文名稱：阿苯達(dá)唑；丙硫達(dá)唑；丙硫咪唑；抗蠕敏；撲爾蟲；腸蟲清
運(yùn)輸條件：Room temperature in continental US; may vary elsewhere.
儲(chǔ)存方式：
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
溶解性數(shù)據(jù)
DMSO : 20 mg/mL (75.38 mM; Need ultrasonic)
H2O : 0.67 mg/mL (2.53 mM; Need ultrasonic)
| 濃度溶劑體積質(zhì)量 | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 3.7689 mL | 18.8445 mL | 37.6889 mL |
| 5 mM | 0.7538 mL | 3.7689 mL | 7.5378 mL |
| 10 mM | 0.3769 mL | 1.8844 mL | 3.7689 mL |
請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲(chǔ)備液；一旦配成溶液，請(qǐng)分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
儲(chǔ)備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 儲(chǔ)存時(shí)，請(qǐng)?jiān)?6 個(gè)月內(nèi)使用，-20°C 儲(chǔ)存時(shí)，請(qǐng)?jiān)?1 個(gè)月內(nèi)使用。
以下溶解方案都請(qǐng)先按照 In Vitro 方式配制澄清的儲(chǔ)備液，再依次添加助溶劑：
——為保證實(shí)驗(yàn)結(jié)果的可靠性，澄清的儲(chǔ)備液可以根據(jù)儲(chǔ)存條件，適當(dāng)保存；體內(nèi)實(shí)驗(yàn)的工作液，建議您現(xiàn)用現(xiàn)配，當(dāng)天使用； 以下溶劑前顯示的百
分比是指該溶劑在您配制終溶液中的體積占比；如在配制過程中出現(xiàn)沉淀、析出現(xiàn)象，可以通過加熱和/或超聲的方式助溶
- 2.
參考文獻(xiàn)
在線客服客服一Albendazole (Synonyms: 阿苯達(dá)唑; SKF-62979)
Albendazole (SKF-62979) 是一種口服有效的廣譜的抗寄生蟲劑，具有高效、低宿主毒性的特點(diǎn)，可用于人類和動(dòng)物胃腸道寄生蟲的研究。Albendazole 可誘導(dǎo)癌細(xì)胞的凋亡和自噬，并抗細(xì)胞增殖和抑制細(xì)胞周期進(jìn)程。Albendazole 還能抑制微管蛋白的聚合和 HIF-1α、VEGF 的表達(dá)，具有抗氧化活性，能抑制癌細(xì)胞的糖酵解過程。
生物活性
Albendazole (SKF-62979) is an orally active and broad-spectrum parasiticide with high effectiveness and low host toxicity, is used for the research of gastrointestinal parasites in humans and animals. Albendazole induces apoptosis and autophagy in cancer cells. Albendazole also inhibits tubulin polymerization and HIF-1α, VEGF expression, has antioxidant activity, and inhibits the glycolytic process in cancer cells[1][2][3][4][5].
IC50 & Target
parasites, tubulin[1][2].
HIF-1α, VEGF[3].
體外研究(In Vitro)
Albendazole (100, 500, 1000 nM; 1, 3, or 5 days) inhibits cell proliferation in a dose-dependent manner[1].
Albendazole (100, 250, 500, 1000 nM; 3 days) arrests SKHEP-1 cells at both G0–G1 (250, 500 nM) and G2-M (1000 nM) phases of the cycle[1].
Albendazole (5 μM; 24, 36 h) mainly induces early apoptosis in HCT-15 cells and late apoptosis in HCT-1 16, HT29, SW480 cells accompanied with cleavage of PARP and caspase-3 in a time-dependent manner[2].
Albendazole (5 μM; 24, 36 h) induces autophagy via increasing autophagy-related protein (such as LC3, Atg7, p-beclin-1, and beclin-1) expression level in HCT-15, HCT-1 16, HT29, and SW480 cells[2].
Albendazole (500 nM, 24 h) inhibits hypoxia-induced HIF-1α expression and VEGF expression in A549 cells[3].
| Cell Line: | SKHEP-1 cells |
| Concentration: | 100, 500, 1000 nM |
| Incubation Time: | 1, 3, or 5 days |
| Result: | Inhibited cell proliferation in a dose-dependent manner. |
體內(nèi)研究(In Vivo)
Albendazole (10 mg/kg; i.g.; once a day for 30 days) reduces Echinococcus granulosus cyst weights in mice[4].
Albendazole (300 mg/kg; p.o.; per day in two divided dose for 20 days) profoundly suppresses tumor growth in vivo[1].
| Animal Model: | Female BALB/c mice (10-week-age; Echinococcus granulosus infection model)[4]. |
| Dosage: | 10 mg/kg |
| Administration: | Oral gavage; once a day for 30 days. |
| Result: | Reduced Echinococcus granulosus cyst weights. |
分子量：265.33
Formula：C12H15N3O2S
CAS 號(hào)：54965-21-8
中文名稱：阿苯達(dá)唑；丙硫達(dá)唑；丙硫咪唑；抗蠕敏；撲爾蟲；腸蟲清
運(yùn)輸條件：Room temperature in continental US; may vary elsewhere.
儲(chǔ)存方式：
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
溶解性數(shù)據(jù)
DMSO : 20 mg/mL (75.38 mM; Need ultrasonic)
H2O : 0.67 mg/mL (2.53 mM; Need ultrasonic)
| 濃度溶劑體積質(zhì)量 | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 3.7689 mL | 18.8445 mL | 37.6889 mL |
| 5 mM | 0.7538 mL | 3.7689 mL | 7.5378 mL |
| 10 mM | 0.3769 mL | 1.8844 mL | 3.7689 mL |
請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲(chǔ)備液；一旦配成溶液，請(qǐng)分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
儲(chǔ)備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 儲(chǔ)存時(shí)，請(qǐng)?jiān)?6 個(gè)月內(nèi)使用，-20°C 儲(chǔ)存時(shí)，請(qǐng)?jiān)?1 個(gè)月內(nèi)使用。
以下溶解方案都請(qǐng)先按照 In Vitro 方式配制澄清的儲(chǔ)備液，再依次添加助溶劑：
——為保證實(shí)驗(yàn)結(jié)果的可靠性，澄清的儲(chǔ)備液可以根據(jù)儲(chǔ)存條件，適當(dāng)保存；體內(nèi)實(shí)驗(yàn)的工作液，建議您現(xiàn)用現(xiàn)配，當(dāng)天使用； 以下溶劑前顯示的百
分比是指該溶劑在您配制終溶液中的體積占比；如在配制過程中出現(xiàn)沉淀、析出現(xiàn)象，可以通過加熱和/或超聲的方式助溶
- 2.
參考文獻(xiàn)
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