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瀏覽器自帶分享功能也很好用哦~該抗體是針對HMGB1的兔多克隆抗體。在免疫組織化學染色和免疫印跡實驗中能識別HMGB1。
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產品詳情
高遷移率族蛋白1(HMGB1)多克隆抗體
Polyclonal Antibody to High Mobility Group Protein 1 (HMGB1)
HMG1; HMG3; SBP1; Sulfoglucuronyl Carbohydrate Binding Protein; Amphoterin; High Mobility Group Box 1 Protein
編號PAA399Ra01
物種Rattus norvegicus (Rat，大鼠) 相同的名稱，不同的物種。
來源多抗制備
宿主兔
效價-
Ig類型IgG
純化方式抗原特異性親和純化
標記物無標記物
緩沖液成份0.01M 磷酸鹽緩沖液（pH7.4，containing 0.05% Proclin-300，50% glycerol）
性狀液體
濃度0.34mg/ml
且適物種Homo sapiens (Human，人), Mus musculus (Mouse，小鼠)
應用WB,IHC
如果抗體需用于流式細胞術，請參見流式抗體。下載英文說明書 中文說明書
規(guī)格20μl100μl 200μl 1ml 10ml
價格￥ 1436
特異性
該抗體是針對HMGB1的兔多克隆抗體。在免疫組織化學染色和免疫印跡實驗中能識別HMGB1。
用法
Western blotting: 0.5-2μg/mL;
Immunohistochemistry: 5-20μg/mL;
Immunocytochemistry: 5-20μg/mL;
Optimal working dilutions must be determined by end user.
儲存
經常使用則4°C保存。-20°C保存不超過兩年。避免反復凍融。
穩(wěn)定性
熱穩(wěn)定性以損失率顯示。損失率是由加速降解試驗決定，具體方法如下：在37°C孵育48小時，沒有明顯的降解或者沉淀產生。保質期內，在適當的條件下存儲，損失率低于5%。
參考文獻
| 雜志 | 參考文獻 |
| Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine | High mobility group box protein-1 (HMGB-1) as a new diagnostic marker in patients with acute appendicitis [PubMed: PMC3094252] |
| Respiration | Protective Effect of Nicotine on Lipopolysaccharide-Induced Acute Lung Injury in Mice [Karger: 000319151] |
| Surgery | Clinical relevance of single nucleotide polymorphisms of the high mobility group box 1 protein gene in patients with major trauma in Southwest China [Pubmed: 22047946] |
| Viral Immunology | Is HMGB1 a New Indirect Marker for Revealing Fibrosis in Chronic Hepatitis and a New Therapeutic Target in Treatment? [Wiley: source] |
| Chinese Medical Journal | Severity of sepsis is correlated with the elevation of serum high-mobility group box 1 in rats [CMJ: 2009218808935901080] |
| Microbiology and Immunology | Diagnostic value of serum concentrations of high-mobility group-box protein 1 and soluble hemoglobin scavenger receptor in brucellosis [PubMed: 23278480] |
| ACTA biochimica polonica | High mobility group B1 levels in sepsis and disseminated intravascular coagulation [Actabp: Source] |
| Anesthesia and Analgesia | The Inhibitory Effect of Lidocaine on the Release of High Mobility Group Box 1 in Lipopolysaccharide-Stimulated Macrophages [PubMed: 21288974] |
| Rheumatology International | Elevated serum levels of high mobility group box protein 1 (HMGB1) in patients with ankylosing spondylitis and its association with disease activity and quality of life [PubMed: 23143556] |
| Inflammation Research | Mammalian target of rapamycin complex 2 regulates inflammatory response to stress [PubMed: 22899279] |
| Acta Biochimica et Biophysica Sinica | IGF-1 alleviates ox-LDL-induced inflammation via reducing HMGB1 release in HAECs [PubMed: 22782142] |
| LabVest | The suppression of TRIM21 and the accumulation of IFN-α play crucial roles in the pathogenesis of osteonecrosis of the femoral head. [PubMed: 22825687] |
| Biomark Insights | Decreased Epidermal Growth Factor (EGF) Associated with HMGB1 and Increased Hyperactivity in Children with Autism [PubMed: PMC3623607] |
| Evidence-based Complementary and Alternative Medicine | ATF3 Protects against LPS-Induced Inflammation in Mice via Inhibiting HMGB1 Expression [PubMed: PMC3770047] |
| Exp Ther Med | Correlation between serum high-mobility group box-1 levels and high-sensitivity C-reactive protein and troponin I in patients with coronary artery disease [Pubmed: 23935732] |
| International of Rheumatic disesases | Serum levels of high mobility group box 1 protein and its association with quality of life and psychological and functional status in patients with fibromyalgia [Pubmed: 23901875] |
| Surgery | A novel serum marker for biliary tract cancer: Diagnostic and prognostic values of quantitative evaluation of serum mucin 5AC (MUC5AC) [Pubmed: 24468034] |
| Acta Pharmacol Sin. | Simvastatin suppresses vascular inflammation and atherosclerosis in ApoE-/- mice by downregulating the HMGB1-RAGE axis [Pubmed: 23564080] |
| BMC pulmonary medicine | Soluble receptor for advanced glycation end-products and progression of airway disease [Pubmed: 24758342] |
| Biochemical Pharmacology | Ascorbic acid reduces HMGB1 secretion in lipopolysaccharide-activated RAW 264.7 cells and improves survival rate in septic mice by activation of Nrf2/HO-1 signals [Pubmed:25896849] |
產品詳情
高遷移率族蛋白1(HMGB1)多克隆抗體
Polyclonal Antibody to High Mobility Group Protein 1 (HMGB1)
HMG1; HMG3; SBP1; Sulfoglucuronyl Carbohydrate Binding Protein; Amphoterin; High Mobility Group Box 1 Protein
編號PAA399Ra01
物種Rattus norvegicus (Rat，大鼠) 相同的名稱，不同的物種。
來源多抗制備
宿主兔
效價-
Ig類型IgG
純化方式抗原特異性親和純化
標記物無標記物
緩沖液成份0.01M 磷酸鹽緩沖液（pH7.4，containing 0.05% Proclin-300，50% glycerol）
性狀液體
濃度0.34mg/ml
且適物種Homo sapiens (Human，人), Mus musculus (Mouse，小鼠)
應用WB,IHC
如果抗體需用于流式細胞術，請參見流式抗體。下載英文說明書 中文說明書
規(guī)格20μl100μl 200μl 1ml 10ml
價格￥ 1436
特異性
該抗體是針對HMGB1的兔多克隆抗體。在免疫組織化學染色和免疫印跡實驗中能識別HMGB1。
用法
Western blotting: 0.5-2μg/mL;
Immunohistochemistry: 5-20μg/mL;
Immunocytochemistry: 5-20μg/mL;
Optimal working dilutions must be determined by end user.
儲存
經常使用則4°C保存。-20°C保存不超過兩年。避免反復凍融。
穩(wěn)定性
熱穩(wěn)定性以損失率顯示。損失率是由加速降解試驗決定，具體方法如下：在37°C孵育48小時，沒有明顯的降解或者沉淀產生。保質期內，在適當的條件下存儲，損失率低于5%。
參考文獻
| 雜志 | 參考文獻 |
| Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine | High mobility group box protein-1 (HMGB-1) as a new diagnostic marker in patients with acute appendicitis [PubMed: PMC3094252] |
| Respiration | Protective Effect of Nicotine on Lipopolysaccharide-Induced Acute Lung Injury in Mice [Karger: 000319151] |
| Surgery | Clinical relevance of single nucleotide polymorphisms of the high mobility group box 1 protein gene in patients with major trauma in Southwest China [Pubmed: 22047946] |
| Viral Immunology | Is HMGB1 a New Indirect Marker for Revealing Fibrosis in Chronic Hepatitis and a New Therapeutic Target in Treatment? [Wiley: source] |
| Chinese Medical Journal | Severity of sepsis is correlated with the elevation of serum high-mobility group box 1 in rats [CMJ: 2009218808935901080] |
| Microbiology and Immunology | Diagnostic value of serum concentrations of high-mobility group-box protein 1 and soluble hemoglobin scavenger receptor in brucellosis [PubMed: 23278480] |
| ACTA biochimica polonica | High mobility group B1 levels in sepsis and disseminated intravascular coagulation [Actabp: Source] |
| Anesthesia and Analgesia | The Inhibitory Effect of Lidocaine on the Release of High Mobility Group Box 1 in Lipopolysaccharide-Stimulated Macrophages [PubMed: 21288974] |
| Rheumatology International | Elevated serum levels of high mobility group box protein 1 (HMGB1) in patients with ankylosing spondylitis and its association with disease activity and quality of life [PubMed: 23143556] |
| Inflammation Research | Mammalian target of rapamycin complex 2 regulates inflammatory response to stress [PubMed: 22899279] |
| Acta Biochimica et Biophysica Sinica | IGF-1 alleviates ox-LDL-induced inflammation via reducing HMGB1 release in HAECs [PubMed: 22782142] |
| LabVest | The suppression of TRIM21 and the accumulation of IFN-α play crucial roles in the pathogenesis of osteonecrosis of the femoral head. [PubMed: 22825687] |
| Biomark Insights | Decreased Epidermal Growth Factor (EGF) Associated with HMGB1 and Increased Hyperactivity in Children with Autism [PubMed: PMC3623607] |
| Evidence-based Complementary and Alternative Medicine | ATF3 Protects against LPS-Induced Inflammation in Mice via Inhibiting HMGB1 Expression [PubMed: PMC3770047] |
| Exp Ther Med | Correlation between serum high-mobility group box-1 levels and high-sensitivity C-reactive protein and troponin I in patients with coronary artery disease [Pubmed: 23935732] |
| International of Rheumatic disesases | Serum levels of high mobility group box 1 protein and its association with quality of life and psychological and functional status in patients with fibromyalgia [Pubmed: 23901875] |
| Surgery | A novel serum marker for biliary tract cancer: Diagnostic and prognostic values of quantitative evaluation of serum mucin 5AC (MUC5AC) [Pubmed: 24468034] |
| Acta Pharmacol Sin. | Simvastatin suppresses vascular inflammation and atherosclerosis in ApoE-/- mice by downregulating the HMGB1-RAGE axis [Pubmed: 23564080] |
| BMC pulmonary medicine | Soluble receptor for advanced glycation end-products and progression of airway disease [Pubmed: 24758342] |
| Biochemical Pharmacology | Ascorbic acid reduces HMGB1 secretion in lipopolysaccharide-activated RAW 264.7 cells and improves survival rate in septic mice by activation of Nrf2/HO-1 signals [Pubmed:25896849] |
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杭州昊鑫生物科技股份有限公司成立于2009年初，坐落于素有“天堂”之稱的杭州, 由一群從事生物領域工作十年以上經驗人士創(chuàng)立
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